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Females and Males lyrica of Reproductive Potential Effects on Spermatogenesis In a randomized, double‑blind, placebo‑controlled non‑inferiority study to assess the effect of pregabalin on sperm characteristics, healthy male subjects received pregabalin at a daily dose up to 600 mg (n=111) or placebo (n=109) for 13 weeks (1 complete sperm cycle) followed by a 13‑week washout period (off‑drug) .
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These subjects took study drug for lyrica at least 8 weeks, had appropriate timing of semen collections and did not have any significant protocol violations .
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3% in the placebo group (2/62) had greater than or lyrica equal to 50% reduction in mean sperm concentrations from baseline at Week 26 (the primary endpoint) .

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